The sitcom was renewed for a sixth season earlier this year, but there was confusion when Wu, who plays Jessica Huang on the ABC series, tweeted that she was "upset" by the renewal.
The actress later clarified her comments by explaining that the renewal meant she had to give up another project she was passionate about, adding that she loves the series and its cast and crew. Following this, the show announced that Wu's role would not be recast.
But just a few months later, ABC has now announced the show's cancellation, with the decision being a creative one, according to The Hollywood Reporter. Its sixth season will last 15 episodes, with the final two serving as the series finale early next year.
"We couldn’t be prouder of this game-changing show and the impact it has had on our cultural landscape," said ABC Entertainment president Karey Burke. "The success of Fresh Off the Boat has helped pave the way for inclusion throughout the industry.
"[Series creator] Nahnatchka Khan and her brilliant creative team have created an unforgettable series with an Asian-American family front and centre, something that hadn’t been done in two decades."
She added: "The cast, led by Randall Park and Constance Wu, is one of the finest and funniest on television. We'll miss the Huang family, and are eternally grateful for the incredibly heartfelt stories they have told these past six seasons."
Fresh Off the Boat airs on ABC in the US and on 5STAR in the UK.
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