A radio news anchor has died in a suspected murder-suicide attempt, with his girlfriend and two children also wounded in the alleged attack.

Jim Matthews, who worked as an overnight anchor at WWJ-AM radio, was tragically killed in Chesterfield in the US state of Michigan on Friday (local time).

Police said the 57-year-old anchor was found dead at the home while his girlfriend, 35, and two children, 5 and 10, were rushed to hospital.

The 54-year-old suspect was also taken to hospital with alleged self-inflicted wounds and overdose where he remains in a stable condition.

Chesterfield Township Public Safety Director Brian Bassett said in a news conference police were alerted to the incident after the 35-year-old woman escaped the home with her five-year-old daughter.

She was suffering from stab wounds and remains in a critical but stable condition. The young girl is also in a stable condition.

Mr Bassett said the 10-year-old boy was found tied up in a closet at the home with blunt force trauma. He is in a critical condition.

Police did not reveal the relationship between the family and the suspect, but it is believed the suspect was welcomed into the home earlier in the day prior to the alleged attack.

"Our investigation has determined that this is an isolated tragedy that does not present a danger to our community at this time," Mr Bassett said.

'Not even something you'd see in a horror movie'

Mr Matthew's brother Joe Nicolai spoke to 7 Action News about his shock following the tragedy.

"It’s not even something you’d see in a horror movie," Mr Nicolai said.

"He loved taking care of his kids, he loved being on the radio.”

"He used to play radio when he was a kid. He would play DJ, that was his passion. He was a really amazing person.”

WWJ radio said Mr Matthews had worked as the overnight news anchor for nearly seven years, and often spoke about his love for his children.

"He loved delivering the latest news to his listeners and was incredibly dedicated to WWJ and the broadcasting industry. There have been many tears shed in our newsroom ... and Jim will be greatly missed," the station said.

A GoFundMe page has been set up by the sister of Mr Matthew's girlfriend to help raise money for the children.

"I am working on getting these kids everything they need. My niece is doing well, but my nephew is in critical condition," she wrote.

"He was forced to undergo brain surgery and ear surgery. He has come through both successfully. He is still currently sedated and is staying in the Pediatric ICU.

"[My husband and I] are taking care of my niece and advocating for my nephew as he goes through the biggest challenge he has yet to face; recovering from a vicious, needless attack."

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