The actress captioned the snap, "Ready for the #weekend!"
Fans were quick to comment on the snap, with one user writing, "You're a queen."
Another added, "So beautiful even without makeup," while someone else agreed, "So naturally beautiful."
Salma is a fan of the bare-faced selfie, recently sharing another with her 15.2 million Instagram followers.
The star has previously opened up about her beauty regime, revealing make-up free days are her best days.
“My favorite [sic] days are the days that you're not wearing makeup, and you're not looking in the mirror because you're not thinking about how you look,” she said in People's Beautiful Issue.
“You’re just present, and you’re just doing your thing.
“And this is the best thing about not wearing makeup, when you’re not thinking, ‘How do I look without makeup? Oh, I forgot to put makeup.’ When you’re just living life, and this is not your priority.”
Salma also recently shared the fact she turns to acupuncture to boost her “health and wellbeing”.
In October, the actress celebrated reaching 12 million followers on Instagram by posting a picture of her back covered in a dozen of the needles.
Salma has been quarantining during the ongoing coronavirus pandemic with her French billionaire husband Francois-Henri Pinault.
Earlier this year, she shared a tribute to him on the 14th anniversary of their first meeting, "Today 14 years ago I met my soul mate. After the test of time and even the test of the quarantine I feel very blessed that I’ve found you, and the more I discover you the more my love grows. Happy anniversary Mi Amor."