Steelers All-Pro S Minkah Fitzpatrick ruled out of Jaguars game with hamstring injury

Pittsburgh lost a key player early in Sunday's showdown with the Jacksonville Jaguars, a game the Steelers lost 20-10.

All-Pro safety Minkah Fitzpatrick fell to the turf with a non-contact hamstring injury in the first quarter and was ruled out shortly after. He grabbed his right leg while running in coverage, then fell to the ground.

He went to the sideline medical tent for evaluation, then went immediately to the locker room, where he was initially listed as doubtful return. Moments later, the Steelers announced that Fitzpatrick was out for the game.

The loss was a significant blow for the 4-3 Steelers. A three-time All-Pro, Fitzpatrick was tied for the NFL lead in interceptions last season with six. He's Pittsburgh's top playmaker and defender in the secondary.

A timeline for Fitzpatrick's return wasn't initially clear. After games against the Tennessee Titans and Green Bay Packers in upcoming weeks, the Steelers face AFC North matchups against the Cleveland Browns and Cincinnati Bengals.

The Steelers entered Sunday having won four out of five games following a Week 1 blowout loss to the San Francisco 49ers. Their defense keyed their strong start, having held opponents to 18 points or fewer in each of their past four wins entering Sunday.