Oprah Winfrey, George Clooney, Jane Fonda and More Join Virtual Carousel of Hope Ball

Oprah Winfrey, George Clooney, Jane Fonda and More Join Virtual Carousel of Hope Ball

Watch a Sneak Peek of Adam Lambert and Cynthia Erivo Performing "I Knew You Were Waiting"

The clip is from the upcoming virtual Carousel of Hope ball.

The legendary Carousel of Hope Ball is going virtual!

Oprah Winfrey, George Clooney, Jane Fonda, Samuel L. Jackson, Cynthia Erivo and Andrea Bocelli are just a few of the stars set to join the 2020 Carousel of Hope Ball on Saturday, October 10.

In partnership with PEOPLE, the Carousel of Hope Ball and the Children’s Diabetes Foundation, which is dedicated to raising funds for clinical care and diabetes research at the Barbara Davis Center for Diabetes, will stream exclusively on PEOPLE.com, PeopleTV as well as PEOPLE Facebook, Twitter and YouTube.

The star-studded charity ball will celebrate host Barbara Davis’ 90th birthday and the 40th anniversary of the center.

"We are looking forward to hosting another sensational event, and bringing together our Carousel of Hope family to raise awareness and funds to fight his life-altering disease," Davis said in a statement. "We could not be more proud to commemorate 40 years of the Barbara Davis Center for Diabetes, and the revolutionary work being done to care for those in need!"

RELATED: Amal and George Clooney Donate $100,000 to Lebanese Charities in the Wake of the Beirut Explosion

Jay Leno will be acting as master of ceremonies, with David Foster serving as music director. The event will be produced and directed by Erich Bergen and Marc Johnston.

There will also be special appearances by many of Hollywood’s biggest stars including Tony Bennett, Dame Joan Collins, Robert De Niro, Josh Groban, Quincy Jones, Adam Lambert, Rob Lowe, Barry Manilow, Diane Warren, Dionne Warwick and more.

Mike Marsland/WireImage; Rodin Eckenroth/Getty;

The ball was created in 1978 and has since been a favorite event in Hollywood circles for a night dedicated to raising diabetes awareness.

The Carousel Balls have raised more than $105 million to date with proceeds benefitting the Children’s Diabetes Foundation and the Barbara Davis Center for Diabetes. The most recent Carousel of Hope Ball, hosted in 2018, honored Robert De Niro with the "Brass Ring Award" and raised over $1.9 million.

For additional information about the 2020 Carousel of Hope Ball, and to reserve a virtual spot, visit: carouselofhope.org.