November 5 marked two years since 10 people were killed and thousands of others injured on that fateful day in Houston, Texas.
The youngest to lose their life was nine-year-old Ezra Blount.
Opening up about it to GQ for their Man of the Year issue, the 32-year-old rapper, who shares two children with ex Kylie Jenner, said: "I always think about it. Those fans were like my family. You just feel for those people. And their families."
Speaking on how that "overly devastating" time affected his creative process with his new album Utopia, Scott said it took "months and months and months" after that night to get back to his music.
"Making music, you think about things that go on in life and things that happen in your life, and you dial in on things. That moment for families, for the city, you know, it was devastating," he added to the publication.
Scott went on to explain that it was "therapeutic" for him to be "able to channel some of the energy into production and sounds and finishing it."
He specifically references the tragic events of that evening in the track My Eyes, which he calls "one of my favourite songs on the album".
The Texas native says it conveys "the things I deal with on a day-to-day basis and the fact of how it could be misunderstood and the struggles of life and all aspects of life."
"The constant weight that's put on," he continued. "That you carry, you know. And just a vision through my eyes."