People in Scotland are bracing for more snow and ice-related disruption, while those in the south of England have been told homes and businesses could be flooded in the coming days.
The warnings come after dozens of schools in northern England and North Wales were closed and travel was disrupted on Thursday.
While amber weather warnings for Wales and the Pennines have passed, yellow warnings for snow and ice are in place for much of Scotland for Friday and Saturday.
The Met Office has said roads and railways are likely to be affected, and there is also a chance people will experience power cuts and disruption to mobile phone services.
Ferry operator Calmac, which operates services between the Scottish mainland and isles, has announced cancellations and delays due to adverse weather.
Two flood warnings have also been issued for Scotland - covering north and south Luce Bay in Dumfries and Galloway - while 81 flood warnings are in place in England, mostly in the South and the Midlands.
A total of 294 less severe flood alerts are in force in England while 19 are active in Wales.
Dozens of schools in northern England and North Wales closed due to snow on Thursday.
The Met Office measured 10cm of snow in Kirkwall, Orkney, while 9cm was recorded in Bingley, West Yorkshire.
In Harbertonford, south Devon, a total of 43.2mm of rainfall was measured - almost half the average for the area in February.
Trains between Bath and Swindon were also disrupted due to flooding.
Temperatures across the UK have been fluctuating, with a low of -13.8C (7.2F) being recorded in the Scottish Highlands in the early hours of Thursday, while a high of 13.6C (56.5) was recorded in Exeter later on the same day.
Met Office meteorologist Dan Stroud said: "We've still got rain and many have snow making its way northwards, we have got further weather warnings in force.
"Temperatures are recovering a little, across the far South it's generally mild.
"We've got a second band of cloud and rain moving northwards, it makes for challenging driving conditions.
"We've had the worst of it but it's still not completely clear. Where we have falling snow we see there is a risk of a few icy patches on roads."
He added that as the focus "is probably starting to shift more towards ice, people should still be cautious".